St. Vincent's hosted the inaugural assembly of the Anglican Church in North America on April 21–25, 2009.

[5] At this meeting, a number of major steps were taken to officially establish the new denomination, including the election of Robert Duncan, bishop of Pittsburgh, as ACNA's first archbishop.

[6][7][8] Rick Warren, a leading American evangelical, and Metropolitan Jonah Paffhausen, leader of the Orthodox Church in America, addressed the audience.

[9] Archbishop of Canterbury Rowan Williams sent retired Seychelles Bishop Santosh Marray of the Province of the Indian Ocean to serve as his observer.

[1] The cathedral has hosted events for Forward in Faith North America[11] and is a member of the American Anglican Council.