St. Vincent's Health System, based in Birmingham, Alabama, United States is an operator of acute care hospitals located in the Birmingham area and a health ministry of Ascension Health.

It was founded by the Daughters of Charity and named after the 17th century Parisian St. Vincent de Paul, who started the Daughters of Charity in 1633.

In 1999, it was part of the founding of Ascension Health.

[1] In July 2007, St. Vincent's Hospital merged with Eastern Health System to become St. Vincent's Health System.

[1] In June 2024, UAB Health System announced it will purchase Ascension St. Vincent's Health System for $450 million.