St. Vincent's Medical Center Southside is a not-for-profit, faith-based hospital located in the southern part of Jacksonville, Florida.

[2][3] Three local Jacksonville women began St. Lukes in 1873 to serve people in the area during the winter tourist season.

[3][6][7] The current facility was opened in December 1984, contained 289 beds, and offered general acute care services and specialized medical/surgical procedures.

In May 2001, the Mayo Clinic revealed that they intended to construct a new teaching hospital on the grounds of its main campus and sell St. Luke's to St. Vincent's HealthCare.

[9] Jacksonville's Memorial Hospital (owned by HCA), fearing a decline in their business, objected to the construction of Mayo's new facilities.

[10] The latest available yearly statistics show that the emergency room had 23,549 patients, they admitted 7,279 persons with 1,264 outpatient and 1,492 inpatient surgeries performed.