This school occupied its new site on 1 May 1998 and has enjoyed the administrative assistance of the Congregation of Jesus (CJ) sisters since 2006.

At its establishment in 1960, the school used the grounds and buildings of Hotel Cecil, well known in the British Raj era, purchased for that purpose.

[2] The luxury hotel, situated on Rajniwas Marg in the Civil Lines area of Delhi[3] in an 11-acre (4.5 ha) park, had over a hundred rooms, large lawns, and a swimming pool.

The Patna Province of the Society of Jesus bought it (including the premises and the services of the hotel employees) from the siblings Mr. Edwin Hotz and Mrs. Pauline White, who were of Swiss/English extraction, and was granted permission by the Commissioner of Delhi to convert it into a residential school for boys and girls (Coed).

St. Xavier's School was inaugurated on 6 January 1960 by the Archbishop His Excellency James Knox, the representative of the Vatican in India, under the stewardship of Jesuit Fr.

Loesch, Rodrigues, and Austin Reinboth in converting the hotel campus into a modern public school.

The prep classes were held in Bombay House while the five buildings of the hotel accommodated some classrooms and dorms with four to five boys in a room which had the unusual facility of a dressing area and attached toilets.

Many of the old buildings were destroyed but some were retained and remain in use, like the Fathers' residence, chapel, hall, Snob's Row, and the swimming pool.

Modern classrooms, teacher's tutorial rooms, science laboratories, a library, and a host of other facilities were constructed and a large playing field created by leveling the ground occupied by a road that had cut across the area.

The school continued its policy of teaching in Hindi in the belief that younger children learn best in their mother tongue.

Esto Vir (Latin for "Be a man") is taken from the farewell instruction of King David to his son and royal successor, Solomon: "I am about to die.