Completed in 1816, and designed by James Gillespie Graham (1776–1855), the church of St. Andrew formally re-introduced the Catholic presence to Glasgow.

However, congregations of other Christian denominations in the city donated money for the completion of the project in a gesture of ecumenism in light of the difficulties faced in construction.

The specification is as follows: Pedals Open Diapason (Mirrlees) 32 Open Diapason 16 Bourdon 16 Octave 8 Flute Bass 8 Choir Hohl Flute 8 Gamba 8 Dulciana 8 Flute Harmonique 4 Piccolo 2 Corno Di Bassetto 8 Great Organ Double Diapason 16 Open Diapason No.1 8 Open Diapason No.2 8 Clarabel Flute 8 Principal 4 Harmonic Flute 4 Fifteenth 2 Mixture 3rks Trumpet 8 Clarion 4 Swell Organ Lieblich Bourdon 16 Open Diapason 8 Lieblich Gedact 8 Salicional 8 Vox Angelica 8 Gemshorn 4 Flageolet 2 Hautboy 8 Cornopean 8 Clarion 4 Couplers Swell to Pedal Choir to Pedal Great to Pedal Swell to Choir Swell Octave to Great Swell to Great As part of the cathedral renovation in 2009/2010 the organ was dismantled and placed in storage by David Wells (Organ Builders Ltd) Liverpool.

Five years later, new premises in the Calton area of the East End provided for 600 people each Sunday until the celebration of the first Mass in the new Church of St Andrew at Clyde Street on 22 December 1816.

Shoppers, workers, students, tourists and passers-by also regularly visit the cathedral – for quiet prayer, for Mass, or for the Sacrament of Reconciliation.

The programme of renovation included the completion of new heating and lighting systems as well as redecoration and gold leaf restoration, installation of newly commissioned bronze doors, the repair and reinstatement of the pipe organ and the installation of a new canvas by Peter Howson depicting the martyrdom of St John Ogilvie.

The work was completed in April 2011, and saw the return of the cathedra to St Andrew's Cathedral from the temporary pro-cathedral of the Archdiocese of Glasgow at Saint Mary's, Calton.