The club became known as St Brendan’s in 1958 to coincide with the change in name of the hospital with which it is closely associated.

The most famous day in the club's history was probably the 1980 Dublin Senior Hurling Championship final win over Faughs.

They lost the 2019 Junior Football Championship Final and were promoted to Intermediate where they remained until 2022.

The Juvenile club is very active in the Dublin 7 community, providing coaching to local schools, running initiatives like Gaelic4Girls, and participating in events such as the Pride of Stoneybatter festival.

A camogie team was set up in 2021 and won a county championship in its first year of existence.