It is situated on Chenies Road (A404), which at that point occupies the boundary of Hertfordshire and Buckinghamshire for a half-mile, adjacent to the north side of the school.

The school was founded in 1862 by the church wardens of St Clement Danes parish in Aldwych, London and opened in Houghton Street.

The school had a well-known choir which featured in a 1975 EMI recording (ASD 3117) of Carl Orff's Carmina Burana, conducted by André Previn with the LSO (and chorus).

The site was next to Hammersmith Hospital, and is now occupied by St Clement's House, a block of flats and Wood Lane High School.

[5] On 29 June 1973, 13-year-old Nicholas St Clair from Fulham was killed on the school playing fields when he was struck in the chest by a javelin thrown by a fellow student.

The Du Cane Road buildings were taken over by Burlington Danes Church of England School, sold to Hammersmith Hospital in 2002 and demolished in 2004.