St James College is an independent Catholic secondary day school for boys and girls, located in Brisbane, Queensland, Australia.

St James College, informally known as Jimmies, was established in 1868 with only 12 students and is the oldest Catholic boys' school in Queensland.

In 1893, the Congregation of Christian Brothers agreed to take over the school following major economic depression, the government's refusal to pay staff wages and inconsistent student enrolment.

Jerome William Long (1834–1891) was the first lay Principal to lead St James between 1871 and 1877, and again in 1880–90, he is accredited with being the first teacher to hold a Class 2, Division 1 certificate in Queensland.

[1] St James College offers a basketball program that is fully inclusive to all levels of ability for both boys and girls.