On 1 March 1902, the station was renamed again as Southport St Luke's, and in June of that year it began serving the Preston line, absorbing the adjacent Southport Ash Street railway station.

They did, however, share the same ticket office, located on the street at St Luke's Road.

On 22 March 1904 the Preston line was electrified all the way up to Crossens,[2] and enabled a regular service to stop at St Luke's.

Trains to Preston (including the Crossens electric shuttle) ended when the line was closed on 7 September 1964, a victim of the Beeching Axe.

[1] The end of St Luke's station came when the Preston platform, still serving a number of trains, finally closed on 9 September 1968.