[1] St Luke ultimately closed in 2002 due to financial issues stemming from the hospital's parent company Tenet Healthcare.

[3] Through much of the late 1990s, Tenet was negatively criticized on numerous occasions for their management of the St Luke as patients and local residents noted the declining service within the hospital despite the then-recent renovations.

[8] On January 5, 2002, Tenet Healthcare announced they would permanently close the facility by the end of the month, citing the hospital's inability to reach fiscal goals for the company dating back to 2000.

Jeffrey Barbakow and Tenet continued to receive criticism after relocating the company's corporate offices to Santa Barbara and later issuing him an undisclosed severance payout following his resignation later that year.

In 2013 the hospital was briefly evaluated by the city of Pasadena for possible reuse as an urgent care facility; however, the proposal was quickly vetoed as the location was deemed too outdated to meet current state standards.

[13] Mehdi Bolour, CEO of Denley Investments, was arrested on September 13, 2018, after investigators had discovered he was involved in operations illegally renting apartments across Los Angeles county.

[13] Bolour's offices had previously been raided by Los Angeles police in May 2018, after it was discovered his associates had been smuggling illegal drugs and firearms to numerous properties owned by Denley.

Facing pressure from Pasadena city council, most of the external graffiti has been painted over and lower level entrances have been barricaded with steel plates.