St Mary's College is a coeducational Roman Catholic secondary school and sixth form located in Cranbrook Avenue, Kingston upon Hull, England.

It was formed following an amalgamation between the former St Mary's Convent High School for Girls and Marist College for boys.

It was later rebuilt and moved to Inglemire Lane in 1960 to become St Mary's Grammar School for Girls, close to the Marist College for Boys on Cottingham Road.

In 1988 after LEA reorganisation, it converted into St Mary's College, a Voluntary Aided, Roman Catholic, Co-Educational and Comprehensive Day school for pupils aged 11–19 in the Diocese of Middlesbrough.

Pupils also join the school from further afield especially from the East Yorkshire area if parents have decided they want their children to have a Catholic education.