St Mary's Lifeboat Station is situated in St Mary's Harbour, Isles of Scilly and has been an important station for the Royal National Lifeboat Institution since the service began in 1837, however without a service between 1855 and 1874.

[1] In 1899 this was replaced by a new station at Carn Thomas with a slipway, at a cost of £1,500 (equivalent to £213,300 in 2023).

[1] In 1902 the slipway was extended by 40 feet (12 m)[2] by Robert Hicks[3] to enable the lifeboat to be launched at any state of the tide.

St Mary's Lifeboat has received fifty-six awards for gallantry, including 26 RNLI medals for bravery, comprising one gold, nine silver and 16 bronze.

The most recent was in 2004 when bronze medals were awarded to Coxswain Andrew Howells and Crew Members Mark Bromham and Philip Roberts for the rescue of an injured man from a yacht on 29 October 2003.