It is located just south of Mortlake High Street and the Anglican St Mary the Virgin Church.

The church building, in Gothic Revival style, was designed by Gilbert Blount, architect to the first Archbishop of Westminster, Nicholas Wiseman, and dates from 1852.

Frances Margaret Taylor (1832–1900), who was founder of the Roman Catholic religious congregation the Poor Servants of the Mother of God, was buried in the churchyard.

[28] The cemetery includes another mausoleum, commemorating the very young Comte de Vezlo, Guilaume Henri (1894–1901).

A plaque near the mauseolum's entrance also commemorates his mother, Annette Rosamonde Blasio, the Comtesse de Vezlo, who died in 1938.

Sir James Marshall (1829–1889), a British colonial judge who helped the spread of Roman Catholicism in Ghana and Nigeria, is buried in the churchyard cemetery.

[7] The Knights and Ladies of Marshall, a lay association of Ghanaian Catholics, visit the church in Mortlake annually to celebrate a Mass in his memory.