St Mary le Strand was an ancient parish in the county of Middlesex, England.

The ancient parish church of St Mary and the Innocents was demolished in 1548 when Somerset House was constructed.

Edward Seymour, recently created Duke of Somerset, promised to provide a replacement, but none was ever built.

The parishioners of St Mary le Strand were made to renounce their claim before they were permitted to use the Savoy Chapel again.

In the annual bills returns from 1726 there is an entry for St Mary le Strand and the Precinct of the Savoy appears separately from 1728.