Deptford St Nicholas was a civil parish in the metropolitan area of London, England.

[1] The creation of the parish accompanied the building of the Church of St Paul's, Deptford, constructed by the Commission for Building Fifty New Churches to meet the demands of the growing population.

St Nicholas parish included the old maritime settlement and the dockyard adjacent to the River Thames.

It was bounded by the River Thames to the north and Deptford Creek to the east.

The union ceased to exist and the parish had no further role in the administration of the poor law following the Local Government Act 1929.