St Nicholas Catholic High School opened as a secondary modern on 6 September 1965, with Michael O'Connor as its first head teacher and Father R. Velarde, Parish Priest of St. Wilfrid's, Northwich as the first Chairman of Governors.

Woods remained Headteacher until Christmas 2022 when he left to become Deputy Director of Schools for the Shrewsbury Diocese.

[4] The school was reassessed in 2019 and downgraded to "good" due, in part, to the performance of disadvantaged students.

[7] As there are few Catholic high schools in Cheshire, St Nicholas' catchment area extends as far away as Helsby and Knutsford.

Buses run from all the mentioned towns and villages to and from St Nicholas, but due to recent cuts the bus service has come under threat.