It was built on land acquired by the La Salle Brothers in 1898 which was originally intended for building a resort bungalow.

During World War II, the school was used by the British as a hospital and later by the Japanese as an administrative building.

In 2002, Lucas Lak Pati Singh, a former vice principal of Changkat Changi Secondary School and an educator of 38 years, was posted into Saint Patrick's as the school's new principal.

By 2019, Aloysius Yong had retired while Adolphus Tan and Joseph Peterson had been posted to other schools.

[1] In keeping with the school's Catholic traditions, students recite the Apostles' Creed in the morning, and the Angelus or the Regina Coeli during Easter at noon.

Saint Patrick's has a military band, which has won gold medals in competitions locally and abroad, from 1990 to 2016.In the 2005 Singapore Youth Festival (SYF), the band won Gold with Honours.

They have achieved the Frank Cooper Sands Gold award for several years running thanks to the high standard of training planned by the teachers and the Patrol Leaders Council.

A notable alumni of the troop is Tony Tan, the seventh President of Singapore.

Selected students also represent their school and participate in the Lasallian Leaders Servant Leadership Camp (LLSLC), where they and students from Lasallian schools in the Philippines interact with each other to learn servant leadership by helping less fortunate communities in the Philippines.