[1] Matthew Mead was minister of the chapel from 1658 until 1662, when he was replaced after the Restoration for being too non-conformist.

Also baptised there were William Henry Perkin, the chemist who discovered the first aniline dye, and Jane Randolph, mother of Thomas Jefferson.

[14] In January 2005, a team from the congregation of Holy Trinity Brompton moved to Shadwell to minister with the existing members of St. Paul's in serving the local area.

[15] St Paul's stands in the charismatic and evangelical Anglican traditions.

[16][17] The church is a pivotal location in James Lovegrove's Sherlock Holmes and the Shadwell Shadows.