The school was established by the Congregation of Christian Brothers in 1937 and is operated under the auspices of Edmund Rice Education Australia.

St Pius X College started in 1937 as Christian Brothers Chatswood,[5] initially going to the Beginner level, with the first Leaving Certificate class graduating in 1941.

Named the Treacy Centre, the facility comprises a variety of sports fields and venues as well as meeting places and classrooms.

It included meeting rooms, stands and basketball courts and can facilitate stage plays (e.g. Pius Talent Show).

[7] The school participates in rugby, cricket, football, basketball, tennis, softball, swimming, squash, chess and athletics.

[8] A house system has existed at St Pius X from before 1952, involving four basic colours of red, green, blue, and gold.

St Pius's Outdoor Education program facilitates personal development and teamwork through camps, excursions and overnight experiences.

Outdoor Education is offered to all students, these experiences enhance learning, build relationships and respect, develop leadership and teamwork, as well as resilience as boys overcome fear and adversity as they push outside their comfort zones.

Highlights of the Outdoor Education Program include: Students in Year 11 have the opportunity of entering the Mock Trial Competition conducted by the Law Society of New South Wales.

During the competition the College's 'legal team' competes against other schools defending and prosecuting 'mock' cases involving assault, larceny, and negligence.