The church is Grade I listed by the Department for Digital, Culture, Media and Sport as a building of outstanding architectural or historic interest.

It is recorded by Dr. Thoroton that a flood which occurred about 1600 the River Trent changed its course, and separated the parish of North Muskham from the hamlet of Holme.

At about the same time, Sir Thomas Barton, the descendant of a wealthy merchant, owned a large house and a great amount of property at Holme, and North Muskham Church benefited from his wealth.

The Barton family coat of arms with impalements and rebus (a bear and a tun), is displayed in various places in the church.

The pulpit is probably late 17th century and may be contemporary with the altar rails; Nikolaus Pevsner describes the screen as "exceptionally fully cusped".