She played college softball for Iowa, being named a three-time all-conference third baseman and shortstop.

[1][2] May-Johnson was selected twelfth overall in the National Pro Fastpitch, eventually playing for the Chicago Bandits.

She earned the 2006 Nokona Rookie of the Year award and was also named to the all-National Pro fastpitch team.

[6] Her position as an assistant coach for the University of Louisville softball team was announced on July 14, 2014.

[13] May-Johnson represented the United States women's national softball team at the 2011 Pan American Games and won a gold medal.