[4] Nissa's debut as a professional team came in a Coppa Italia Serie C match against Reggina, which ended in a 2–2 home tie.

[4] This was followed by a financial crisis that caused a relegation to Promozione in 1989; the club promptly returned to Interregionale the following season, but only to be cancelled from football due to bankruptcy in 1992.

In the following years, Nissa fought hard to go on its rise into the football pyramid, without succeeding in it until 2008, when it won the Girone A of Eccellenza Sicily after a long battle with Trapani.

In 2024, Nissa were crowned Eccellenza Sicily champions, thus winning promotion to Serie D.[5] Its official colours are red and yellow.

Nissa plays their home matches at Stadio Marco Tomaselli, informally known as Pian del Lago, with a capacity of 11,950.