It was originally named the Stadio Vittorio Emanuele III, after the King of Italy, but it was re-named in honour of Nicola de Simone, a Siracusa player who died as a result of an accidental kick to the side of the head he had received during a game against Palma Campania on 13 May 1979.

Stadio Nicola de Simone was originally built in 1930, during the years of fascism in Italy, as can be seen in symbols which are still visible in the architecture of the stadium's main entrance.

The stadium underwent minor renovations to its locker rooms and stands in 2001, which included the installation of a field watering system and of 700 blue seats (to match Siracusa's colors) in the grandstand.

Along with the renovation, a synthetic turf field was built nearby for practices and the youth squad, named after former Siracusa manager Paul Quattropani.

During 2009, further structural interventions were carried out, as requested by the Lega Pro inspector and which concerned the installation of plexiglass fences in all sectors of the stadium; the construction of the security room where CCTV cameras connected to the Police Headquarters are installed; the resizing of the pitch according to the parameters required by the professional championships; the extension of the West Curve; the expansion of the Guest Sector in the East Curve to 500 seats, and finally the creation of new emergency exits.