The North Bothnia Line is under planning, and will in a future allow high-speed trains to run to Luleå.

Two passenger night trains to and from Stockholm Central Station, operated by Vy Tåg to Swedish Transport Administration specification, travel along part of the railway between Umeå and Boden.

Norrtåg provide up to three daily trains per direction between Umeå, Boden and Luleå, with one continuing to/from Haparanda from April 2021.

An additional train makes two daily roundtrips between Umeå, Vindeln, and Hällnäs, where it leaves the Main Line and continues inland to Lycksele.

Although most trains are powered by the 15 kV overheard supply, the line between Hällnäs and Lycksele is not electrified, so Norrtåg use a single Bombardier Itino Diesel multiple unit for these services.