His father, Stanisław Orzechowski, was a Catholic nobleman and courtier at the court of King John I Albert.
His mother was a Ruthenian noblewoman, Yadviga Baranetska, a daughter of an Orthodox priest.
In 1526 he continued his education at the University of Kraków (a document shows the date of 5 August 1526).
There he came under the influence of the Church reformer Martin Luther and fellow humanist Philip Melanchthon.
His father, not wanting him to convert to the Protestant rite, soon enough ordered him to leave Wittenberg.