Napoli managed to earn an upset victory over the favourites, by winning 2–1, with goals scored by Piotr Zieliński and Lorenzo Insigne.

Lobotka played for over an hour and was replaced by Diego Demme, as Napoli led 2–1, after goals by Arkadiusz Milik and Elif Elmas.

[16] Lobotka had also been added to Napoli's UEFA Champions League squad, thus making him eligible to participate in the Round of 16 fixtures against Barcelona.

[20] Later, Lobotka was called up to multiple fixtures, but had to wait for his competitive debut until 1 September 2017, for a 2018 FIFA World Cup qualifier against Slovenia.

He played the entire match being a valuable midfielder, fulfilling the expectations following the successful performances of Lobotka and Slovakia U21 at the 2017 UEFA European Under-21 Championship, as well as his move to Celta Vigo.

He scored after he tackled and took the ball from Marcus Rashford and exchanged a pass with Adam Nemec, before beating Joe Hart in the 3rd minute of the match.

By the end of the year, he scored again in a friendly match against Norway in the 93rd minute, providing Slovakia a 1-0 victory in a final international game of Ján Ďurica.