The ceremony was held in Singapore on 24 April 2022 at the MES Theatre @ Mediacorp and was hosted by Chen Hanwei.
Romantic drama My Star Bride won a leading three awards including the Best Drama Serial, followed by Recipe Of Life winning two awards for the lead acting roles respectively by Chen's seventh and Huang Biren's fourth, the latter tying Zoe Tay's most number of Best Actress' wins.
Two celebrities, Dennis Chew and Zheng Geping were conferred the All-time Favourite Artiste, while Felicia Chin and Rebecca Lim won their tenth Top 10 Most Favourite Artiste, the latter being the ninth celebrity to win the Top 10 award for ten consecutive times.
A repeat telecast of the Star Awards 2022 will be aired from 2pm to 6.30pm on 1 May 2022 on Mediacorp Channel 8.
Eligible artistes were shortlisted to participate in a nationwide poll of 1,000 people representing an equal breakdown across various age groups across Singapore's demographic, called "Popularity Survey".
On 24 April 2022, the results were revealed during the Star Awards 2022 – Backstage LIVE.
The ceremony's theme, "When the Stars Align, Dreams Come True" (星光荟聚 ，筑梦视界), paid tribute to the challenges caused by the COVID-19 pandemic in Singapore while delivering celebrations with an award show to honour Singapore's content and artistes.