He also works with Penny Arcade in graphic design, as well as co-hosting the PAX gaming conventions and appearing in their collaborations with Wizards of the Coast and Chaosium, Inc. Straub graduated from the University of California, Los Angeles, with a degree in computer science.

The first two volumes Curious Little Thing and Angleworm pair horror with a quirky tone to explore themes of community and tradition,[13] among others.

In 2012, ShiftyLook announced that Straub and Kurtz were co-producing a new animated web series, Mappy: The Beat, in which they also voiced all the characters.

They uncover increasingly disturbing shared memories of the program before discovering that Candle Cove was merely half an hour of TV static which they, as children, had collectively perceived as a story.

[20] Some critics cite Straub and Local 58 as having solidified conventions which would go on to define the genre[21] and even indirectly influence feature-length horror films such as Skinamarink (2022).

[24] Straub has co-hosted numerous podcasts, most of which center around the online comic industry, daily life, or comedy talk shows.

[27] In this same time period, Straub and Kurtz also produced two joint podcasts, The Kris and Scott Power Hour[28] and Daily Affirmation.

[29] From 2009 to 2012, Straub also hosted the comedy internet radio talk show Tweet Me Harder with David Malki.

[32] Beginning in January 2015, Straub and Neumann began hosting Morning Rush, which ended in June 2015 after 16 episodes.

[34] The series is a collaboration between Penny Arcade and Wizards of the Coast, and was eventually canonized in the official D&D Sourcebook Acquisitions Incorporated.

[37] In 2022, Straub took over for Penny Arcade's Mike Krahulik to co-host some key PAX events with Jerry Holkins.