This state highway touches the cities of Dondaicha, Shevade, Mehergaon, Kusumbe, Malegaon, Manmad, Yeola, Kopargaon, Shirdi Rahata, Rahuri, Ahmednagar, Kashti, and Daund.

The highway runs a distance of XXX miles and traverses through Yeola, Nandgaon, Chandawad and Malegaon talukas.

This road serves as a connecting link between the three districts and runs almost parallel to the Daund-Manmad railway line.

It crosses river Godavari near Kopargaon, the Pravara near Kolhar, the Mula near Rahuri and the Bhima near the district border where there are bridges.

This highway starts from Dondaicha city in Sindkheda Taluka of Dhule District and proceeds South West towards Kusumbe.

After crossing Dongrale village, it continues for southwards another 27.2 km (16.9 mi) where it enters Malegaon city.

After traveling for another 5.7 km (3.5 mi), near Kaulane village the State Highway 16 starts off and proceeds south-east towards Nandgaon while this highway proceeds south-west for another 14.5 km (9.0 mi) where it exits Malegaon taluka just after Chondhi village and enters Chandwad taluka.

After crossing Savargaon village it continues southwards for another 6 km (3.7 mi) where it enters Yeola city.

After crossing Yesgaon village, it continues southwards for another 5.2 km (3.2 mi) where it enters Kopargaon city.

After crossing Kopargaon city it continues southwards where it exits the taluka just before Sawali Vihir Bk.

Then this highway continues southwards for another 0.9 km (0.56 mi) where it exits Rahata taluka just after crossing Pravara river near Kolhar Bk.

Further traveling for 9.7 km (6.0 mi), another branch of State Highway 49 branches off at this junction and proceeds east towards Shevgaon in Ahmadnagar district while this highway continues southwards where it exits Rahuri taluka just before near Nandgaon village and enters Ahmadnagar taluka.