SR 75 crosses the Tennessee state line from State Route 44 in the Holston Valley, formed by the South Fork Holston River.

It crosses the low McConnell Ridge at Green Spring into the Watauga Valley, and after running through that valley for a while it turns north to cross the Great Knobs, mostly along a small creek.

SR 75 enters the town of Abingdon and crosses Interstate 81/U.S.

[6] U.S. Route 19 was added from Abingdon northwest to Hansonville in the late 1920s.

[7] Thus, SR 110 was split in the 1933 renumbering; the short piece northwest of Hansonville became part of State Route 71 (which mainly replaced State Route 107).