[1][2] Just south of Glade Spring, SR 91 intersects US 11 (Lee Highway) and continues north as Maple Street through a diamond interchange with I-81 and into the town.

The state highway receives the northern end of the business route, Glade Street, east of downtown.

SR 91 crosses over Norfolk Southern Railway's Pulaski District and exits the town on Crescent Road, which passes through McCall Gap in Walker Mountain.

The state highway briefly follows Laurel Creek through the Freestone Valley before ascending Flattop Mountain near Tannersville.

The gravel road continues for about 5.5 miles (8.9 km) on the state highway's crossing of Clinch Mountain.

The highway runs 1.38 miles (2.22 km) between intersections with SR 91 on the south and east sides of the town.