St. George Coast Guard Station, or the Staten Island Coast Guard Station, located adjacent to the Staten Island Ferry St. George Terminal, is a complex of 22 historic buildings and was best known for the invention and manufacturing of lighthouse equipment.

The Office Building and U.S. Light-House Depot Complex, designed by Alfred B. Mullet and completed in 1865, are listed on the National Register of Historic Places, and comprise an official New York City Landmark.

In the late 1990s, New York City Economic Development Corporation (EDC) took over the site and created a public plaza; a public fishing pier (Pier 1); a fully functioning building that was supposed to house a gift shop for the National Lighthouse Museum.

The present site of the St. George Coast Guard Station was the location of the New York Marine Hospital, also known as the Quarantine, which opened in 1799[4] or 1800.

[6] The Quarantine was New York City’s first line of defense against immigrant-borne infectious diseases like Smallpox, Cholera, Typhus and Yellow fever.

[7] After a series of epidemics in the 1850s, a riotous mob of locals burned the twenty buildings of the hospital complex to the ground in the Staten Island Quarantine War of 1858.

Subterranean storage areas, called "The Vaults", were built to store fuels and other combustible materials for lighthouses, and an entire machine shop and foundry where anchors, sinkers, chains, buoys, and lighthouse structural members were fabricated were all in full operation by the 1920s.

With the USLHS's merger into the US Coast Guard in 1939, the Staten Island Depot continued its work, but during World War II it became more of a ship repair and outfitting space as many USCG Cutters, buoy tenders and harbor patrol craft called the Depot for wartime repainting, arming and voyage repairs.

Budget cuts and Consolidation in the late 1960s saw much of the Staten Island Depot's workload sent to the USCG Yard at Curtis Bay, Baltimore, Maryland.

The decline continued even after the Office Building was designated as a New York City landmark in 1980,[2] and the entire site was listed on the National Register of Historic Places in 1983.