Ruzowitzky's first international co-production, All the Queen's Men (2001), starring Matt LeBlanc and Eddie Izzard, was received poorly by both critics and viewers.

[3] In 2013, he directed the 90-minute non-fiction drama Das radikal Böse, which, by means of authentic letters and interviewing psychology, military, and history experts seeks to explain the mentality of "ordinary" members of Einsatzgruppen and Wehrmacht soldiers that carried out the Holocaust.

It was mainly based upon Christopher Browning's 1992 book Ordinary Men, which assigns the efficiency of the German killing machinery to social mechanisms of conformism and peer pressure rather than racial hatred.

[5][6] On 2 May 2014, Deadline Hollywood announced that Ruzowitzky would direct Screen Gems' action-thriller Patient Zero based on an original script by Mike Le.

The cast included his Counterfeiters star Karl Markovics in the non-singing role of Samiel; the production was conducted by Bertrand de Billy.