[1] Born in Pizzo Calabro, De Sando began his acting career during the mid-1970s, when he was mentored on stage by Vittorio Gassman.
[2][3] He later made several appearances on film and television, acting in Alberto Negrin's docudrama Mussolini and I[2] and working multiple times with director Lamberto Bava.
[4] De Sando is well known as a voice dubber as he is the official Italian voice of Robert De Niro,[4][5] dubbing over him for the first time in The Mission,[3] later taking on the role definitively since Ferruccio Amendola’s death in 2001.
[2] Other actors De Sando dubs include James Gandolfini, Ciarán Hinds, Ben Kingsley, John Goodman and many more.
His animated dubbing roles include Clayton in Tarzan, Don Lino in Shark Tale, Buck Strickland in King of the Hill and various characters in The Simpsons.