The series tells the story of Alita (or Gally in the original Japanese version and several other languages) continuing her quest to uncover her mysterious past.

In November 2024, Yukito Kishiro stated on his personal blog that Mars Chronicle will end with chapter 56 in volume 11, and that the story will be continued in a new series with a new title.

Going into space with new and old companions alike, to look for her lost friend Lou Collins and to find out more about her forgotten past, Alita is caught up in an interplanetary struggle between the major powers of the colonized solar system.

Along the way, she forms an alliance with three of the Alita Replicas who have now begun to think for themselves, an unsavory superhacker, and Nova himself when she enters the Zenith of Things Tournament (Z.O.T.T.

During the course of the story, more background about the setting of Battle Angel Alita that was not disclosed in the prior series is revealed, such as how the Earth emerged from a cataclysmic impact winter that wiped out most of the population.

The central hub with artificial gravity houses a whole city and vast war game areas, where people made immortal by nanotechnology pay to fight for fun.

Mars, the first planet to be colonized by Earth, is currently under a four-way civil war with almost every side secretly being backed by one of the major powers of the Solar System.

A number of orbital cities form the République Vénus (Venus Republic) and provide homes for a race of transhuman people with grotesque physiques and a liking of vile debauchery such as quasi-cannibalism.

The virus causes mutations in the DNA which result in the carriers exhibiting vampire-like characteristics, most notably pronounced canines and a thirst for blood.

[5] Kishiro's requirements were apparently rejected by Shueisha and Kodansha subsequently announced that Last Order will join Evening's, starting with its 101st chapter in the 2011 8th issue, released on March 22, 2011.