Stephen I (Georgian: სტეფანოზ I, Step'anoz I or Stephanoz I; died 628), of the Guaramid Dynasty, was a presiding prince of Iberia (Kartli, central and eastern Georgia) from c. 590 to 627.

He made Tbilisi his capital and defended it with a Georgian-Sasanian force from the army of Byzantine emperor Heraclius allied with the Khazars (see Byzantine–Sasanian War of 602–628).

When Stephen switched from a pro-Byzantine position to cooperation with the Sasanid Empire, his religious sympathies shifted toward anti-Chalcedonism, leading to its official adoption by the catholicos of Iberia in 598 or 599.

On the reverse of his coins, instead of the sacred flame (Atar), the principal emblem of Zoroastrianism, he placed the Cross – symbol of the victory of Christianity.

[5][6] The exterior stone plaque of the church of the Holy Cross at Mtskheta, Georgia, mentions the principal builders of this church: Stephanos the patricius, Demetrius the hypatos, and Adarnase the hypatos who have traditionally been equated by the Georgian scholars with Stephen I, son of Guaram; Demetre, brother of Stephen I and Adarnase I.