Amos has performed stand up at the Edinburgh Festival Fringe every year since 2003, after making his debut in 2001.

During the 2006 Fringe, he performed the revealing solo show All of Me, in which he publicly acknowledged his own homosexuality to his audience for the first time.

[3] As an actor, he performed in both the Edinburgh Fringe and London run of a version of One Flew Over the Cuckoo's Nest.

Amos hosted, and performed a short set on the main stage at London's Gay Pride parade on 3 June 2010.

In 2022, Amos appeared in the West End cast of My Fair Lady at the London Coliseum, playing Alfred P Doolittle.

In the United Kingdom, Amos has appeared as a guest on panel shows such as Have I Got News for You, Mock the Week, QI, The Wright Stuff and And Then You Die.

In March 2007, his documentary on homophobia in the black British community and Jamaica, Batty Man, was broadcast by Channel 4.

He has also appeared in Rich Hall's Cattle Drive, EastEnders, Stewart Lee's Comedy Vehicle and as a featured performer on BBC One's Live at the Apollo after Dara Ó Briain and before Frankie Boyle.

Amos has the distinction of being one of the few stand-up comics chosen to appear at the 2007 Royal Variety Performance.

Amos made an appearance on the gala/comedy gig We Are Most Amused, an ITV1 televised production on 15 November 2008, in celebration of The Prince of Wales' 60th Birthday.

On a related note, he gently mocks political correctness, in one of his favourite recurring jokes referring to his own penis size: "some stereotypes I can live with!"

[8] In March 2010, Amos appeared with the England rugby squad playing Nelson Mandela, in a comedy sketch for the BBC's Sport Relief.

Amos is currently featured in the BBC Radio 4 show The Odd Half Hour, which began broadcasting on 16 November 2010.

[16] On Fern Britton's The 5 O'Clock Show (Channel 4, 19 July 2010), he stated that his middle name is Kehinde, which is a Yoruba name for "second of twins".