[6] Lewis's daughter, Ilana Landsberg-Lewis, was the foundation's executive director since its formation in 2003 until 2020, and its African Advisory Board is chaired by Graça Machel.

[13] On September 7, 2013, the foundation hosted a people's tribunal in Vancouver, BC, to shine a light on the discrimination and inequality faced by African grandmothers who are supporting communities and children affected by HIV/AIDS.

Six grandmothers from across sub-Saharan Africa presented personal testimonies to four Tribunal judges: Theo Sowa, Mary Ellen Turpel-Lafond, Joy Phumaphi and Gloria Steinem.

It has supported initiatives in Botswana, the Democratic Republic of the Congo, Eswatini, Ethiopia, Kenya, Lesotho, Malawi, Mozambique, Namibia, Rwanda, South Africa, Tanzania, Uganda, Zambia, and Zimbabwe.

[16] In evaluating funding applications from prospective partners, the foundation places particular emphasis on the involvement of women, community members, and people living with HIV and AIDS in decision-making processes.