Since 16 July 2005, Nolan has presented his own weekend phone-in show for BBC Radio 5 Live,[7] airing from 10 pm to 1 am every Friday and Sunday, and from 9pm to 12am every Saturday.

[8] In 2006, Nolan was involved in a mock boxing match with Gerry Anderson in aid of the BBC's Children in Need appeal.

[10] Following coverage of the Bobby Storey funeral during the COVID pandemic, Sinn Fein – the largest nationalist political party – began boycotting the show.

[11] The SDLP also began to boycott the radio programme after the abrupt, on-air removal of the SDLP's Stormont leader, Matthew O'Toole, in March 2023 over comments about the spokesman for the Loyalist Communities Council, an umbrella group which issues statements on behalf of some loyalist paramilitary groups.

[12] The Irish Times reported that in April 2023 a "heated" meeting took place between the SDLP and BBC Northern Ireland director Adam Smyth, with party leaders raising concerns about the balance of the programme's contributors and editorial accountability.

Smyth sent the party an email in late June 2023, confirming that an assessment of "content" on the program over a "typical one month period" had been performed to address the issues mentioned in the meeting.

The BBC's Executive Complaints Unit concluded that Nolan was justified in stopping O'Toole's participation during the 3 March broadcast.

[14] In 2013, a new series, Story of a Lifetime, hosted by Nolan, began with episode one focusing on the life of his Radio Ulster colleague Hugo Duncan.

[20] In 2023, Nolan was accused by multiple employees of "bullying and harassment", fostering a "siege mentality", and sending unsolicited sexually explicit images.