He is known for his work with numerous heavy metal bands such as Sadus (of which he was a co-founder), Death, Testament, Megadeth, Sebastian Bach, Iced Earth, Autopsy, Obituary, Control Denied, Dragonlord and Charred Walls of the Damned, and he has performed on over 50 albums as a guest, session or full-time band musician.

[1] Di Giorgio has played bass guitar in heavy metal and death metal bands such as Death,[2] Autopsy,[3] Control Denied,[4] Ephel Duath,[5] Obscura,[6] Artension, Faust, Memorain, Painmuseum, Suicide Shift, Soen,[7] Vintersorg,[8] Dragonlord,[9] Iced Earth,[10] Sebastian Bach,[11] Obituary,[12] Megadeth,[13] and is a founding member of Sadus.

In October 2019, he founded the fusion-world-metal group Quadvium with fellow fretless bass player Jeroen Paul Thesseling.

Di Giorgio has stated that his main influences as a bassist are Geddy Lee, Chris Squire, Geezer Butler, Steve Harris, Stanley Clarke, Jaco Pastorius, Billy Sheehan, Dave Pegg and Charles Meeks.

[37] Di Giorgio endorses Ibanez Guitars and primarily plays a number of different fretted and fretless BTB basses.