She has earlier played for Brøndby IF of Denmark's Elitedivisionen and FC Fleury 91 in the Division 1 Féminine.

[2] On 30 July 2020, Larsen signed for newly-promoted Aston Villa in the Women's Super League.

Larsen made her senior international debut for Denmark in January 2015, starting a 1–1 friendly draw with New Zealand in Belek, Turkey.

Although she began her national team career as a defender, versatile Larsen was named as a forward for a UEFA European Championship 2017 qualifying Group 4 win over Slovakia in June 2016.

[3] Due to tournament-ending injuries to teammates Janni Arnth and Mie Leth Jans, Larsen was reverted to playing as a defender for the national team at the UEFA European Championship 2017 and has been a starter in the defence since.