Co-signatories agree to outlaw nine of the dirty dozen chemicals, limit the use of DDT to malaria control, and curtail inadvertent production of dioxins and furans.

At the first meeting of the Conference of the Parties (COP1), held in Punta del Este, Uruguay, from 2–6 May 2005, the POPRC was established to consider additional candidates nominated for listing under the convention.

The Committee first determines whether the substance fulfills POP screening criteria detailed in Annex D of the convention, relating to its persistence, bioaccumulation, potential for long-range environmental transport (LRET), and toxicity.

Finally, if the POPRC finds that global action is warranted, it develops a risk management evaluation, according to Annex F, reflecting socioeconomic considerations associated with possible control measures.

POPRC-7 considered three proposals for listing in Annexes A, B and/or C of the convention: chlorinated naphthalenes (CNs), hexachlorobutadiene (HCBD) and pentachlorophenol (PCP), its salts and esters.

The criteria for forwarding a proposed chemical to the risk profile preparation stage are persistence, bioaccumulation, potential for long-range environmental transport (LRET), and adverse effects.

[23] From a developing country perspective, a lack of data and information about the sources, releases, and environmental levels of POPs hampers negotiations on specific compounds, and indicates a strong need for research.

[24][25] Another controversy would be certain POPs (which are continually active, specifically in the Arctic Biota) that were mentioned in the Stockholm Convention, but were not part of the Dirty Dozen such as perfluorooctane sulfonate (PFOS).