Under the direction of founder Peanut Butter Wolf, Stones Throw has released music ranging from hip hop to experimental psychedelic rock.

[5] The label has released hip hop records including Madvillainy, the acclaimed[6] debut from Madvillain (a collaboration between producer Madlib and rapper MF Doom) in 2004, and J Dilla's Donuts in 2006.

In addition to hip-hop, artists on Stones Throw's roster work in genres including funk and soul, electronic, indie pop, psychedelic rock, jazz, and more.

R&B singer Mayer Hawthorne debuted on Stones Throw in 2008 with the single "Just Ain't Gonna Work Out" / "When I Said Goodbye", which was released on a red heart-shaped 7" record.

The feature-length film, directed by Jeff Broadway, depicts the label's evolution from the initial collaboration between Hicks and Manak to Stones Throw's influence on mainstream hip hop.

Mild High Club, the psychedelic pop project helmed by musician Alex Brettin, released their debut album Timeline in 2015.

In 2022, she released her follow-up album Natural Brown Prom Queen, which received "universal acclaim" according to Metacritic,[11] and performed at festivals including Glastonbury, Coachella, Fujirock and Bonnaroo.

In 2018 Stones Throw opened Gold Line, a cocktail bar featuring a collection of 7,500 vinyl records and hosting all-vinyl DJ sets.