One of the largest of its kind in France, the museum houses extensive collections of paintings, sculpture, graphic arts, multimedia and design from the period between 1870 (Impressionism) and today, as well as a wide range of pieces in its photographic library.

[1] The building is located at the edge of the old quarter of the city (Petite France), in front of the administrative center of the department (École nationale d'administration) and near the architecturally important baroque weir Barrage Vauban and the medieval tower bridge Ponts couverts.

[2] A further accent is set by contemporary German painters (Markus Lüpertz, Eugen Schönebeck, Georg Baselitz, Jörg Immendorff, A. R. Penck, Albert Oehlen, Daniel Richter, Jonathan Meese, Thomas Scheibitz, Wolf Vostell etc.

The Musée d’Art Moderne et Contemporain de Strasbourg also owns the first cubist painting ever purchased by a public French collection, "Still Life" (1911) by Georges Braque, acquired in 1923, as well as the first painting by Dante Gabriel Rossetti purchased by a public French collection, "Joan of Arc Kissing the Sword of Deliverance" (1863), acquired in 1996 (now displayed in the Musée des Beaux-Arts).

In 1999 a French court ordered that the museum restitute to a Jewish family a work by Gustav Klimt (Die Erfülling) looted by the Nazis during World War II.

The Klimt had been owned by Karl Grunwald, an Austrian art dealer and was confiscated in 1940 when the Nazis invaded France and sold at public auction in 1943.