Strathfield South is located between Liverpool Road (Hume Highway) and the Cooks River, bordered on the east by Coronation Parade and to the west by the Enfield Marshalling Yards.

[citation needed] Father John Joseph Therry was granted 19 hectares (47 acres) in March 1837.

To finance the building of the original St. Anne's Church (foundation stone laid July 1841) Father Therry offered 1.6-hectare (4-acre) blocks for £25, but insufficient money being available, a further 134 allotments were offered for sale in 1854 and the streets of the subdivision named after Saints or dignitaries of the Church.

[3] St Anne's Church is listed on the New South Wales State Heritage Register.

[4][5] The area around St Anne's Village and to the west of Cooks River was locally known as Bark Huts.

[citation needed] The Village of St Anne's and the southern part of the Redmire Estate became known as Druitt Town.

Under this proposal, northern Belfield would form part of Strathfield South, from which it was separated by the Cooks River.

The next most common countries of birth were China 7.5%, India 6.2%, Sri Lanka 4.3%, South Korea 3.9% and Italy 2.2%.

Other languages spoken at home included Mandarin 7.2%, Cantonese 6.5%, Arabic 5.6%, Tamil 5.4% and Korean 5.2%.

The part of the suburb west and south of the Cooks River is entirely industrial, and includes the large Enfield Intermodal Logistics Centre.