Stratum granulosum

[1] Keratinocytes migrating from the underlying stratum spinosum become known as granular cells in this layer.

These cells contain keratohyalin granules, which are filled with histidine- and cysteine-rich proteins that appear to bind the keratin filaments together.

Therefore, the main function of keratohyalin granules is to bind intermediate keratin filaments together.

[2][3] At the transition between this layer and the stratum corneum, cells secrete lamellar bodies (containing lipids and proteins) into the extracellular space.

This results in the formation of the hydrophobic lipid envelope responsible for the skin's barrier properties.