Streatham Park later passed to Ralph's son Henry Thrale, who with his wife, Hester Thrale, entertained many of the leading literary and artistic characters of the day, most notably the lexicographer Samuel Johnson, who was fond of a summer house in the grounds.

Former residents and guests of Streatham Park, or "Streathamites", include many notable 18th-century people: Samuel Johnson, David Garrick, Arthur Murphy, Joshua Reynolds, William Seward, James Boswell, Oliver Goldsmith, Giuseppe Marc'Antonio Baretti, Edmund Burke, Edwin Sandys, William Henry Lyttelton, Sir Robert Chambers, Charles Burney and Frances Burney, along with James and Hester Thrale.

Streatham Park was later leased to the prime minister Lord Shelburne, and was the venue of the negotiated peace with France in 1783.

The Streatham Park mansion was demolished in 1863 and the estate and adjacent fields were laid out for suburban development.

The remaining pre-war buildings include Dixcote (8 North Drive), a rare urban example of a house by the Arts and Crafts architect Charles Voysey.