Street of Chance is a 1930 American pre-Code film directed by John Cromwell and starring William Powell, Jean Arthur, Kay Francis and Regis Toomey.

Wealthy bond broker John Marsden is actually “Natural Davis” a famed and powerful New York gambler with strict standards—he never “cheats, frames or double-crosses,” and “it's final for those who do”.

He is devoted to his wife, Alma, who is filing for a legal separation, and to his impressionable younger brother, "Babe” who has shaken a gambling problem and just married Judy.

Driven to despair by John's obsession with gambling, Alma plans to leaves the city that night.

On Times Square, Babe—who has been tipped off by his San Francisco gambling contacts—asks paperseller Tony where to find Natural Davis.

Babe has a naive view of gamblers, singing the praises of Davis, despite John's warnings: “It won’t look so easy to you someday when you’ve got to knock some guy off or take one in the belly yourself.” John insists on taking the $10,000 back before putting Babe in the game.

A furious Dorgan, thinking he's been double crossed, leaves the game to scour the streets looking for “Natural”.

On the Westbound train, Babe resists the temptation to join a card game and embraces Judy.

Informants and “friends” ignore him, but loyal Tony tells Alma to get him out of town, They call all over, leaving messages.

At the speakeasy, John receives a farewell telegram from Judy, and then a message, supposedly from Babe, telling him to come to the Holland House.