The plant is most often found near shaded stream banks and in moist thickets of the montane and subalpine zones across most of North America.

[8] It is also found in central and southern Europe (from Spain to Ukraine and as far north as Germany and Poland) and in eastern Asia (Japan, Korea, Myanmar (Burma) and eastern Russia (Yakutia, Amur, Kamchatka, Sakhalin, Kuril Islands, Khabarovsk, Primorye)).

[9] Streptopus amplexifolius was used as a food plant by Native Americans in Eastern North America and as a medicine.

Also False Solomon's Seal is always a single unbranched stem, while Twisted Stalk can be branched at the bottom.

In fruit, Twisted Stalk is easily identified by its large, juicy red berries which grow from each leaf axil and are highly visible, even in the thickest undergrowth, as they boldly contrast with the surrounding foliage.