In order to secure accreditation with the AMA, Loyola became one of the first medical schools to administer its own entrance exam to prospective students, thereby ensuring that the applicants were fully qualified.

By the end of Spalding's term as Regent in 1917, the standards of the school had been raised sufficiently to earn it an "A" rating from the AMA.

[5] The Chicago College of Medicine and Surgery owned property and physical facilities ideally situated near the 2,700 bed Cook County hospital.

The Stritch School of Medicine’s state-of-the-art building, dedicated to a new curriculum founded on principles of active learning and early clinical experience, opened in July 1997.

The first year includes Molecular Cell Biology and Genetics, anatomy, physiology and immunology as its four main blocks.

Second year includes Neuroscience, Pharmacology, Mechanisms of Human Disease (Pathology, Microbiology) and Behavioral Science, with the three latter classes being woven through three blocks concurrently.

These aspects of the medical education are taught through lectures, small groups, mentoring and preceptor programs in a vertical curriculum of a class entitled "Patient-Centered Medicine."